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Celebrex treats inflammation by preventing the body's synthesis of a chemical called prostaglandin. Individuals who have developed allergic reactions from aspirin or other NSAIDs may experience an allergic reaction to Celecoxib and should not take Celecoxib. Celecoxib is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, the dose usually is 100 mg twice daily or 200 mg as a single dose.