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It is not used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired.

"Prednisone, are commonly used to suppress the immune system. Prednisone is used as replacement therapy in patients whose adrenal glands are unable to produce sufficient amounts of cortical. It works by modifying the body's immune response to various conditions and decreasing inflammation."

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