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Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisolone is a corticosteroid medicine. Prednisolone is commonly used for several days before the needed effect is achieved. Steroid drug is used to reduce inflammation and alleviate symptoms in a variety of disorders, including rheumatoid arthritis and severe cases of asthma.