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Nexium is usually taken once a day at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. Esomeprazole reduce the production of acid in the stomach and intestines by blocking the enzyme in the wall of the stomach that produces acid.

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Clopidogrel should be used with caution. While you are taking Clopidogrel. A recent study has shown that patients receiving aspirin plus the proton pump inhibitor Esomeprazole had a lower incidence of recurrent ulcer bleeding than patients receiving Clopidogrel.