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You may need a dose adjustment or special tests to safely take Prednisolone. Prednisolone is a corticosteroid medicine. Steroid medication needs may change if you have surgery or a medical emergency. Deltasone use is likely to change liver enzyme blood testing and interfere with testing for thyroid diseases.

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"Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisone is inactive in the body and, in order to be effective, first must be converted to Prednisolone by enzymes in the liver."