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"Pay special attention to how you are responding while on this medicine. Pay special attention to how you are responding while on this medicine. Clinical studies with Topamax, many people with migraines experienced significantly fewer attacks, enabling them to help manage their condition. It is especially important that your doctor knows if you are taking digoxin, contraceptive pills, amitriptyline, or anti-epileptic drugs, such as anxiety, rapid speech, or thoughts of suicide."