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Nexium is usually taken once a day at least one hour before meals, swallowed whole and shouldn't be crushed or chewed. Esomeprazole provides improved acid control in patients with gastroesophageal reflux disease. Esomeprazole reduce the production of acid in the stomach and intestines by blocking the enzyme in the wall of the stomach that produces acid. Decreasing stomach acid can help ulcers to heal and reflux, or heartburn symptoms to subside. Esomeprazole is available with a doctor's prescription and is commonly called by its brand name, Nexium.