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"Spironolactone belongs to the class of diuretics, the medications used to treat fluid retention that occurs with congestive heart failure, cirrhosis of the liver and nephritic syndrome. Some patients are recommended to take Spironolactone twice a day with breakfast if you are pregnant, likely to become pregnant or breastfeeding unless your doctor tells you otherwise."

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"Use of Esomeprazole in pregnant women has not been appraised. Nexium is usually taken once a day at least one hour before a meal."