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Your doctor will tell you how long you will need to take Nexium. Nexium is used to treat ulcers, gastroesophageal reflux disease, and other conditions caused by excess stomach acid. Esomeprazole capsules should be applied one hour before a meal. Nexium decreases the amount of acid backing up into the esophagus and causing reflux symptoms. When you buy Nexium from the merchants listed on our website, all orders are confidential.