Valtrex is most effective if it is started within 48 hours of when the rash first appears. Once-daily Valtrex is also the only medication proven to reduce the amount of time for an outbreak if taken soon enough. There are no studies that show how well Valaciclovir will work if you take it more than 24 hours after the start of symptoms. Aciclovir, the active metabolite of Valaciclovir, if appropriate.
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