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You have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Prednisone is the most commonly-prescribed oral corticosteroid. It is not used in the management of adrenal insufficiency unless a more potent mineral corticoid is administered concomitantly. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired.
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