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"Metformin works by helping to restore your body's proper response to the insulin you naturally produce, and by decreasing the amount of glucose you absorb from your food and the amount of sugar that your liver makes and that your stomach absorbs."

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Fluconazole increases the concentration of Celecoxib in the body by inhibiting the breakdown of Celecoxib in the body by inhibiting the breakdown of Celecoxib in the liver. Celecoxib does not prevent the progression of either type of arthritis. Celebrex works by blocking the action of a substance in the body called cyclo-oxygenase.