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Due to the differences in the way proteins are made in bacteria and humans, the macrolide antibiotics do not influence the production of proteins in humans. Taking Zithromax the following side-effects may be observed abdominal pain, diarrhea or loose stools, nausea, and pain in the abdomen. The Antibiotic drug tests have shown that these drugs are effective in fighting bacterial infections and Azithromycin is known to be amongst the best opportunistic infection fighting drugs in the world.