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The usual dosage of Doxycycline is 100 mg daily starting one or two days before arrival in the malarias area and continuing through the trip and for four weeks after departure. You can suddenly find yourself fighting an infection. For any surgery, let the surgeon know if you are going to use Doxycycline to prevent any health conditions you have or any drugs you are taking Doxycycline, tell your doctor if you have liver or kidney disease.