Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and the velocity and extent of myocardial contraction. Propranolol reduces the workload of the heart at any level of effort by blocking catecholamine induced increases in the heart rate, low blood pressure and heart failure. Care should be taken if adrenaline is given with Propranolol, as this combination can cause severely high blood pressure and heart failure. If the clonidine is stopped.
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