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Valaciclovir is a drug, an esterified version of aciclovir that has greater oral bioavailability than aciclovir. How to take the drug based on the reason it is prescribed. Valaciclovir is an antiviral drug used in the management of herpes simplex and herpes zoster As you learn more about genital herpes and Valaciclovir, you'll realize that you can still enjoy an active life and take charge.