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"Zithromax is used to treat infections of the upper or lower airways, skin or soft tissue, or ears. Antibiotics destroy some useful bacteria that in general live in the digestive system. The intestine. There is a possibility of rare but very serious reactions to Zithromax, and serious skin diseases. Zithromax is an unusual antibiotic in that it stays in the body for quite a long time as it has a prolonged half-life that allows for once a day dosing and also for short-term treatment courses for most infections, Azithromycin is normally considered free of interactions with the majority of other medicines."