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You have surgery or a medical emergency. Prednisone has very little mineral corticoid activity, so it is not used in the management of inflammatory conditions or diseases in which the immune system plays an important role. If you have a fungal infection anywhere in your body. You have any unusual stress such as a serious illness, fever or infection, or if you have a fungal infection anywhere in your body. Prednisone is the most commonly-prescribed oral corticosteroid.
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