Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body. Prednisone typically does not produce immediate effects and must be used for several days before the needed effect is achieved. Prednisolone works by acting within cells to prevent the release of substances in the body that cause inflammation. Deltasone may not work as effectively in people with liver disease whose ability to convert prednisone to Prednisolone is impaired. Prednisone may interact with estrogens and phenytoin.
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